Ross (Jason Schwartzman) is an addict badly in need of some speed. A visit to his dealer, Spider Mike's (John Leguizamo)--where fellow "tweakers" Nikki (Brittany Murphy)--a stripper, Frisbee (Patrick Fugit)--a metalhead, and Cookie (Mena Suvari)--Mike's girlfriend--turns into an odyssey, though, when Mike can't find his stash. Nikki tells Ross that her boyfriend, crazed cowboy The Cook (Mickey Rourke), can supply whatever he needs. The two of them visit The Cook at his motel lab, and Ross quickly gets his fix. Ross, however, is put into service as The Cook's errand boy and chauffeur, with only brief periods of freedom to check up on the stripper girlfriend he left tied to his bed back at his apartment. Ross' three days without sleep reaches a feverish head when it becomes evident that two cops (Peter Stormare and Alexis Arquette) have raided Spider Mike's pad in search of The Cook.

This relentlessly crude and graphic feature from Swedish music video director Jonas Ackerlund is not for the faint-of-heart. Lightening-fast edits, sexually explicit animation, Farrelly-Brothers-level rudeness, and a pervasive sense of nihilism swirl together to create a morally empty Los Angeles of seedy abodes and cinder-block strip malls inhabited by corrupt cops and thrill-seeking lawbreakers. Set to a memorable score by Billy Corgan, Mickey Rourke's memorable turn paves the way for a game young cast.