The boys are back! This time they're turning San Francisco upside down in search of an elusive and extremely violent drug lord. In this sequel to 48 HRS, Reggie (Eddie Murphy) is finishing out a jail term for his earlier crimes; meanwhile, his former partner, Cates (Nick Nolte), has spent the past four years trying unsuccessfully to track down a vicious drug dealer. When Reggie is released from jail, he is horrified and frightened to learn that Cates' dealer has put a warrant out for his life. But when he brings it to the attention of the police department, they seem unwilling to help either partner locate the criminal. Reggie suspects that the department is involved with the dealer--and he's determined to find out how.