Set in 1795 England, And Now the Screaming Starts! tells the tale of blissful newlyweds Catherine (Stephanie Beacham) and Charles Fengriffen (Ian Ogilvy) who move into his ancestral family mansion. On their wedding night, Catherine is raped by a malevolent spirit. She is further plagued by a series of haunting visions involving an eyeless woodsman and a murderous disembodied hand.

Can a savage act of depravity and violence committed by one of Charles' ancestors be to blame? Charles fears that his bride is going insane and calls for Doctor Whittle (Patrick Magee). Unable to help Catherine overcome her visions, Dr. Whittle calls for assistance from a fellow practitioner, Dr. Pope (Peter Cushing), who uses reason and logic to combat what he assumes is a mental disorder. In time, Dr. Pope finds himself fighting a losing battle against the forces of the supernatural carrying out a bloody family curse.

An inconsiderate young couple moves into a house already inhabited by a dismembered and disgruntled hand in the 1973 cult classic AND NOW THE SCREAMING STARTS. Catherine (Stephanie Beacham) is a lovely young bride set to start a new life with her wealthy new husband Charles (Ian Ogilvy.) But a horrid curse has haunted Charles' aristocratic bloodline, and only the help of the brilliant Dr. Pope can help squelch the supernatural evil of the disembodied hand.