Earl Keese (John Belushi) is a slightly overweight, fairly average guy who is approaching middle age. He leads a reasonably comfortable life with his family in their suburban home... until the house next door is bought by a truly odd couple, Vic (Dan Aykroyd) and Ramona (Cathy Moriarty), who quickly proceed to drive Earl crazy. Vic's lunatic behavior has Earl running in circles while Ramona's coarse seductiveness leaves him panting. In short, Earl's tranquil life is suddenly turned upside down.