Director Prachya Pinkaew and star Tony Jaa reunite for this sequel that finds Kham (Jaa) on the run after being blamed for the murder of elephant-camp owner Boss Suchart. When all evidence points to Kham as the killer, he must clear his name and find his elephant with Boss Suchart's vengeful twin nieces (Jija Yanin Wismitanan and Teerada Kittisiriprasert) in hot pursuit. Fortunately for Kham, Interpol agent Sergeant Mark (Mum Jokmok) is willing to lend a helping hand. But things get complicated when ruthless crime lord LC (RZA) attempts to add Kham to his prized collection of world-class fighters, and send him on a secret mission.