Nearly a year after the vampire siege of Barstow, Alaska, lone survivor Stella (Kiele Sanchez) discovers that she isn't alone when she's recruited to eradicate the vampire menace once and for all. Her waking hours filled mourning the death of her late husband and her dreams haunted by visions of the creatures that turned him into a monster, Stella becomes the subject of much ridicule when she makes it her mission to convince the public that vampires truly exist. But just as the embarrassment is becoming too much to handle, three strangers (Harold Perrineau, Diora Baird and Rhys Coiro) present Stella with an opportunity to seek revenge by killing Lilith (Mia Kirshner), the vampire queen behind the Barstow massacre. Armed to the teeth and ready to die fighting, the brave quartet descends into the sewers beneath Los Angeles and begins their search for the elusive Lilith. But should she manage to find them first, the vampires will once again gain the upper hand.