In this sequel, James and Mollie Urbiacco (John Travolta and Kirstie Ally) and their two kids have two new talking additions to the family: a pair of dogs named Rocks (DeVito) and Daphne (Keaton). James has obtained his pilot's licence and now commands the private plane for the head of a cosmetics company (Lysette Anthony). When he must fly her on Christmas Eve, he realizes that she may have designs on him, leaving Mollie and the kids to try and get to him before something terrible happens.
Now that the Ubriacco children are really talking, little Mikey can tell his parents that he wants a dog for Christmas. After mom finally consents to Mikey's choice of a scruffy canine, dad is asked to dogsit a snobby poodle, Daphne, owned by his sexy boss -- who herself holds secret longings for Daphne's handsome caretaker. As the two dogs start to bicker, so do the "parents". Soon, it is up to the furry creatures to cease their own fighting to save the marriage.