Young Charlie and his family have just moved to Cleveland, where his parents are working at the Cleveland Clinic. There, he meets Annie, a three-legged Springer Spaniel who seems to have positive effect on all she meets. Annie has just had puppies, which will be destroyed if they don't find homes. Desperate to help his new friends, Charlie goes on a quest to find homes for the dogs. This family adventure is based on the best-selling children's book ANNIE LOSES HER LEG BUT FINDS HER WAY by Sandra J. Philipson.