Young nihilistic Jack (Jared Leto) has a sleazy affair, bedding a woman with underworld connections. He must then flee for his life from her shady associates who are out for his blood. He joins up with his kooky buddy Pilot (Jake Gyllenhal) and the two hit the road in a beat up, but photogenic jalopy, top down. Their destination is Seattle, but they do make some pit stops along the way where they encounter a gaggle of freaks and hitmen as well as Cassie (Selma Blair), a sexy drifter who joins them in their quest. Reaching their northwest shangri-la, they come across a vigil for the recently departed rock icon Kurt Cobain.
A wild road picture about mortality and the paths of fate and destiny, HIGHWAY moves to the beat of the nineties grunge scene in both attitude and its musical pacing. Rich Robinson of the Black Crowes contributes the original score.